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243 Despite being linked to T-cell dysfunction and poor cancer prognosis, obesity has paradoxically been shown to enhance the response to anti-PD-1/PD-L1 immunotherapy

Their complementary mechanisms one acting primarily through growth factor upregulation and GI-cytoprotection, the other through actin polymerization and systemic cell migration make them uniquely interesting both individually and as a combined research subject

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Similarly, the same mutation in rodents also causes increased ROS in Schwann cells and leads to death of primary Schwann cells in culture